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Issue 26, 2017
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Sophopterocarpan A, a novel pterocarpine derivative with a benzotetrahydrofuran-fused bicyclo [3.3.1] nonane from Sophora flavescens

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Abstract

Sophopterocarpan A (1), with a novel benzotetrahydrofuran-fused bicyclo [3.3.1] nonane ring, was isolated from the roots of Sophora flavescens Ait. Its unusual structure, including its stereochemistry, was determined on the basis of a comprehensive spectroscopic data analysis. A plausible biogenetic pathway for 1 is presented. Sophopterocarpan A was identified as a potential autophagy activator. Additionally, it was found that 1 exhibited cytotoxic activity in MCF-7 cells with an IC50 of 29.36 μM.

Graphical abstract: Sophopterocarpan A, a novel pterocarpine derivative with a benzotetrahydrofuran-fused bicyclo [3.3.1] nonane from Sophora flavescens

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Publication details

The article was received on 23 May 2017, accepted on 23 Jun 2017 and first published on 23 Jun 2017


Article type: Communication
DOI: 10.1039/C7OB01261F
Citation: Org. Biomol. Chem., 2017,15, 5480-5483
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    Sophopterocarpan A, a novel pterocarpine derivative with a benzotetrahydrofuran-fused bicyclo [3.3.1] nonane from Sophora flavescens

    H. Zhu, Y. Yang, K. Xu, J. Xie, Z. Feng, J. Jiang and P. Zhang, Org. Biomol. Chem., 2017, 15, 5480
    DOI: 10.1039/C7OB01261F

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