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Metal-free synthesis of isatin oximes via radical coupling reactions of oxindoles with t-BuONO in water

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Abstract

A metal-free method for the synthesis of isatin oximes was developed through the radical coupling reactions of oxindoles with t-BuONO. This protocol provides a practical and environmentally benign method for the construction of C–N bonds in water at room temperature without using any other reagents. The advantages of this strategy are its mild reaction conditions and clean procedure.

Graphical abstract: Metal-free synthesis of isatin oximes via radical coupling reactions of oxindoles with t-BuONO in water

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Publication details

The article was received on 19 May 2017, accepted on 06 Jun 2017 and first published on 06 Jun 2017


Article type: Communication
DOI: 10.1039/C7OB01235G
Citation: Org. Biomol. Chem., 2017, Advance Article
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    Metal-free synthesis of isatin oximes via radical coupling reactions of oxindoles with t-BuONO in water

    W. Wei, W. Zhu, W. Ying, Y. Wu, Y. Huang and H. Liang, Org. Biomol. Chem., 2017, Advance Article , DOI: 10.1039/C7OB01235G

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