Jump to main content
Jump to site search


Borylated Oximes: Versatile Building Blocks for Organic Synthesis

Abstract

Herein, we demonstrate the synthesis and functionalization of α-boryl aldoximes from α-boryl aldehydes, with no sign of C-to-N boryl migration. Selective modification of the oxime functionality enables access to a wide range of borylated compounds, such as borylated heterocycles and N-acetoxyamides. By reducing the α-boryl aldoximes, MIDA deprotection yields the corresponding β-boryl hydroxylamines. As part of this study, we also demonstrate the utility of the boryl aldoxime motif in peptide conjugation.

Back to tab navigation

Supplementary files

Publication details

The article was accepted on 04 Sep 2017 and first published on 11 Sep 2017


Article type: Communication
DOI: 10.1039/C7CC06579E
Citation: Chem. Commun., 2017, Accepted Manuscript
  •   Request permissions

    Borylated Oximes: Versatile Building Blocks for Organic Synthesis

    S. K. Liew, A. E. Holownia, D. B. Diaz, P. A. Cistrone, P. E. Dawson and A. K. Yudin, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC06579E

Search articles by author

Spotlight

Advertisements