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Issue 59, 2017
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An alkylating immobilization linker for immunochemical epigenetic assessment

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Abstract

A bifunctional linker molecule containing nitrogen mustard and a cyclic disulfide group has been developed for the covalent immobilization of intact DNA, which allows quantitative analysis of epigenomic modification in immobilized DNA using SPR-based immune sensing.

Graphical abstract: An alkylating immobilization linker for immunochemical epigenetic assessment

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Publication details

The article was received on 14 Apr 2017, accepted on 29 Jun 2017 and first published on 30 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC02883K
Citation: Chem. Commun., 2017,53, 8308-8311
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    An alkylating immobilization linker for immunochemical epigenetic assessment

    T. Kurinomaru, N. Kojima and R. Kurita, Chem. Commun., 2017, 53, 8308
    DOI: 10.1039/C7CC02883K

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