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Direct access to N-unprotected tetrasubstituted propargylamines via direct catalytic alkynylation of N-unprotected trifluoromethyl ketimines

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Abstract

Direct catalytic alkynylation of N-unprotected trifluoromethyl ketimines is reported for the first time. A combination of catalytic amounts of diethylzinc and carboxylic acids promoted the reactions under proton-transfer conditions, allowing an unprecedented direct access to N-unprotected α-tetrasubstituted primary amines without additional deprotection steps.

Graphical abstract: Direct access to N-unprotected tetrasubstituted propargylamines via direct catalytic alkynylation of N-unprotected trifluoromethyl ketimines

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Publication details

The article was received on 23 Mar 2017, accepted on 20 Apr 2017 and first published on 27 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC02194A
Citation: Chem. Commun., 2017, Advance Article
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    Direct access to N-unprotected tetrasubstituted propargylamines via direct catalytic alkynylation of N-unprotected trifluoromethyl ketimines

    K. Morisaki, H. Morimoto and T. Ohshima, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC02194A

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