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Issue 27, 2017
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Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages

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Abstract

Phospho-ceramide analogue-1 (PCERA-1), a synthetic analogue of ceramide-1-phosphate (C1P), has been previously shown to act as a potent modulator of macrophage activity and inflammation. We have developed an efficient synthesis of PCERA-1 from readily available starting materials, and designed and prepared derivatives of this analogue, including a photoaffinity probe to tag and identify putative proteins that bind PCERA-1.

Graphical abstract: Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages

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Publication details

The article was received on 11 Dec 2016, accepted on 08 Mar 2017 and first published on 10 Mar 2017


Article type: Communication
DOI: 10.1039/C6CC09849E
Citation: Chem. Commun., 2017,53, 3842-3845
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    Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages

    R. Dandela, R. Mashiach, R. Adepu, R. Gregor, M. Athamna, E. Zecharia, O. Ernst, T. Zor and M. M. Meijler, Chem. Commun., 2017, 53, 3842
    DOI: 10.1039/C6CC09849E

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