Issue 27, 2017

One-pot synthesis of alternating peptides exploiting a new polymerization technique based on Ugi's 4CC reaction

Abstract

We developed a one-pot synthetic technique for alternating peptides. Central to this technique is a new, catalyst-free polymerization based on Ugi's 4CC reaction. The treatment of imines with the ambident molecules bearing both an isocyanide and a carboxylic acid afforded alternating peptides.

Graphical abstract: One-pot synthesis of alternating peptides exploiting a new polymerization technique based on Ugi's 4CC reaction

Supplementary files

Article information

Article type
Communication
Submitted
24 Nov 2016
Accepted
12 Mar 2017
First published
13 Mar 2017

Chem. Commun., 2017,53, 3846-3849

One-pot synthesis of alternating peptides exploiting a new polymerization technique based on Ugi's 4CC reaction

Y. Koyama and P. G. Gudeangadi, Chem. Commun., 2017, 53, 3846 DOI: 10.1039/C6CC09379E

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