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Biphasic Drug Release from Electrospun Polyblend Nanofibers for Optimized Local Cancer Treatment

Abstract

The application of biphasic release profile furnished by electrospun polyblend nanofibers to local cancer treatment was investigated. By adjusting the weight ratio of hydrophilic polymer (Poly(ethylene oxide), PEO) and hydrophobic polymer (Poly(L-lactide), PLA), PEO10-PLA90 fiber with typical biphasic release kinetic was successfully manipulated. Owing to the unique release profile, PEO10-PLA90 fiber in vivo could quickly access to high drug content in the tumor site within 1 h and keep high level for longer than two weeks. In vivo antitumor and safety studies demonstrated that PEO10-PLA90 fiber could achieve optimized local cancer treatment efficacy and avoid undesired adverse reaction. The biphasic drug release profile provided by polyblend electrospun technology was proved to be a new conception for local chemotherapy.

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Publication details

The article was received on 08 Nov 2017, accepted on 30 Nov 2017 and first published on 30 Nov 2017


Article type: Paper
DOI: 10.1039/C7BM01018D
Citation: Biomater. Sci., 2017, Accepted Manuscript
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    Biphasic Drug Release from Electrospun Polyblend Nanofibers for Optimized Local Cancer Treatment

    G. Kuang, Z. Zhang, S. Liu, D. Zhou, X. Lu, X. Jing and Y. Huang, Biomater. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7BM01018D

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