Jump to main content
Jump to site search

Issue 9, 2017
Previous Article Next Article

ε-Polylysine-based thermo-responsive adsorbents for immunoglobulin adsorption–desorption under mild conditions

Author affiliations

Abstract

Thermo-responsive adsorbents for immunoglobulin G (IgG) employing ε-polylysine (EPL) as a polymer backbone were developed. The introduction of mercaptoethylpyridine (MEP) as an IgG-binding ligand and hydrophobization of side chains afforded thermo-responsive IgG adsorbents, whose thermo-responsive IgG desorption ratio was up to 88% (EPL/MEP derivative 3m). The changes in surface densities of active MEP groups, which are caused by thermal conformational changes of the adsorbents, play key roles for IgG desorption. Although a trade-off of IgG adsorption capacity and IgG desorption ratio was observed, the present study offers a novel molecular design for thermo-responsive adsorbents with high synthetic accessibility and potentially low toxicity.

Graphical abstract: ε-Polylysine-based thermo-responsive adsorbents for immunoglobulin adsorption–desorption under mild conditions

Back to tab navigation

Supplementary files

Publication details

The article was received on 29 Apr 2017, accepted on 06 Jun 2017 and first published on 08 Jun 2017


Article type: Communication
DOI: 10.1039/C7BM00390K
Citation: Biomater. Sci., 2017,5, 1751-1755
  •   Request permissions

    ε-Polylysine-based thermo-responsive adsorbents for immunoglobulin adsorption–desorption under mild conditions

    M. Maruyama and K. Shibuya, Biomater. Sci., 2017, 5, 1751
    DOI: 10.1039/C7BM00390K

Search articles by author

Spotlight

Advertisements