Issue 9, 2017

MRI-guided tumor chemo-photodynamic therapy with Gd/Pt bifunctionalized porphyrin

Abstract

Porphyrin derivatives have been widely applied in MR imaging and photodynamic cancer therapy. We here report a novel Gd/Pt bifunctionalized porphyrin derivative (Gd/Pt-P1) for MRI-guided chemo-photodynamic cancer therapy. Gd/Pt-P1 was prepared from tetra(4-pyridyl) porphyrin (P1) via step by step coordination to cisplatin and gadolinium (Gd(III)). Gd/Pt-P1 showed a particularly high synergetic chemo-photodynamic antitumor effect in vivo with a tumor inhibition rate (TIR) of 96.6% and excellent MR imaging performance.

Graphical abstract: MRI-guided tumor chemo-photodynamic therapy with Gd/Pt bifunctionalized porphyrin

Supplementary files

Article information

Article type
Communication
Submitted
15 May 2017
Accepted
12 Jun 2017
First published
13 Jun 2017

Biomater. Sci., 2017,5, 1746-1750

MRI-guided tumor chemo-photodynamic therapy with Gd/Pt bifunctionalized porphyrin

B. Wu, X. Li, T. Huang, S. Lu, B. Wan, R. Liao, Y. Li, A. Baidya, Q. Long and H. Xu, Biomater. Sci., 2017, 5, 1746 DOI: 10.1039/C7BM00431A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements