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Issue 1, 2016
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A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process

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Abstract

A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated reduction. The machine can be used for the synthesis of an array of analogues or the scale up of an individual target.

Graphical abstract: A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process

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Publication details

The article was received on 23 Nov 2015, accepted on 23 Dec 2015 and first published on 07 Jan 2016


Article type: Paper
DOI: 10.1039/C5RE00082C
Citation: React. Chem. Eng., 2016,1, 101-105
  • Open access: Creative Commons BY license
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    A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process

    J. Poh, D. L. Browne and S. V. Ley, React. Chem. Eng., 2016, 1, 101
    DOI: 10.1039/C5RE00082C

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