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Issue 1, 2016
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Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

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Abstract

An automated continuous reactor for the synthesis of organic compounds, which uses online mass spectrometry (MS) for reaction monitoring and product quantification, is presented. Quantitative and rapid MS monitoring was developed and calibrated using HPLC. The amidation of methyl nicotinate with aqueous MeNH2 was optimised using design of experiments and a self-optimisation algorithm approach to produce >93% yield.

Graphical abstract: Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

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Publication details

The article was received on 20 Oct 2015, accepted on 25 Nov 2015 and first published on 01 Dec 2015


Article type: Paper
DOI: 10.1039/C5RE00083A
Author version available: Download Author version (PDF)
Citation: React. Chem. Eng., 2016,1, 96-100
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    Online quantitative mass spectrometry for the rapid adaptive optimisation of automated flow reactors

    N. Holmes, G. R. Akien, R. J. D. Savage, C. Stanetty, I. R. Baxendale, A. J. Blacker, B. A. Taylor, R. L. Woodward, R. E. Meadows and R. A. Bourne, React. Chem. Eng., 2016, 1, 96
    DOI: 10.1039/C5RE00083A

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