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Issue 44, 2016
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Highly enantioselective synthesis of spirocyclopropyloxindoles via a Rh(II)-catalyzed asymmetric cyclopropanation reaction

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Abstract

A chiral dirhodium(II) carboxylate complex catalyzed enantioselective cyclopropanation reaction of N-Boc diazooxindoles with olefins, including aryl, alkyl, cyclic, and disubstituted olefins, under mild conditions is described. This reaction provides complementary access to the corresponding chiral spirocyclopropyloxindole products in good to high yields with good to excellent enantioselectivities.

Graphical abstract: Highly enantioselective synthesis of spirocyclopropyloxindoles via a Rh(ii)-catalyzed asymmetric cyclopropanation reaction

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Publication details

The article was received on 04 Oct 2016, accepted on 18 Oct 2016 and first published on 18 Oct 2016


Article type: Communication
DOI: 10.1039/C6OB02160C
Citation: Org. Biomol. Chem., 2016,14, 10357-10361
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    Highly enantioselective synthesis of spirocyclopropyloxindoles via a Rh(II)-catalyzed asymmetric cyclopropanation reaction

    Y. Chi, L. Qiu and X. Xu, Org. Biomol. Chem., 2016, 14, 10357
    DOI: 10.1039/C6OB02160C

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