Jump to main content
Jump to site search

Issue 44, 2016
Previous Article Next Article

Visible-light-promoted synthesis of phenanthridines via an intermolecular isocyanide insertion reaction

Author affiliations

Abstract

An isocyanide insertion reaction promoted by the combination of an amide and a photoredox is now presented. By using visible light, 6-amidophenanthridine derivatives can be prepared in good chemical yields under mild and eco-friendly reaction conditions. The reaction was shown to proceed through an electron transfer sequence by mechanistic experiments, and thus enabled the efficient production of 24 compounds, each with one new intramolecular aromatic ring obtained. The synthesized compounds were tested to embody good antitumor, antimicrobial and neuraminidase inhibitory activities.

Graphical abstract: Visible-light-promoted synthesis of phenanthridines via an intermolecular isocyanide insertion reaction

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 28 Sep 2016, accepted on 11 Oct 2016, published on 12 Oct 2016 and first published online on 12 Oct 2016


Article type: Paper
DOI: 10.1039/C6OB02113A
Citation: Org. Biomol. Chem., 2016,14, 10407-10414
  •   Request permissions

    Visible-light-promoted synthesis of phenanthridines via an intermolecular isocyanide insertion reaction

    H. Zhou, X. Z. Deng, A. H. Zhang and R. X. Tan, Org. Biomol. Chem., 2016, 14, 10407
    DOI: 10.1039/C6OB02113A

Search articles by author