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Issue 44, 2016
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A metal-free cyclic iminium induced one-pot double annulation cascade: access to dihydroisoquinolinium (DHIQ) salts

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Abstract

A reactive cyclic iminium induced one-pot Groebke–Blackburn–Bienayme (GBB) double annulation cascade (DAC) for the synthesis of skeletally diverse DHIQ salts has been described. The key features of this protocol are transition-metal and solvent-free, mild reaction conditions, robust method, one-step construction of two privileged heterocyclic rings, clean reaction profile and operational simplicity.

Graphical abstract: A metal-free cyclic iminium induced one-pot double annulation cascade: access to dihydroisoquinolinium (DHIQ) salts

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Publication details

The article was received on 23 Sep 2016, accepted on 18 Oct 2016 and first published on 18 Oct 2016


Article type: Communication
DOI: 10.1039/C6OB02089E
Citation: Org. Biomol. Chem., 2016,14, 10366-10370
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    A metal-free cyclic iminium induced one-pot double annulation cascade: access to dihydroisoquinolinium (DHIQ) salts

    A. Sagar, V. Nagarjuna Babu, A. H. Shinde and D. S. Sharada, Org. Biomol. Chem., 2016, 14, 10366
    DOI: 10.1039/C6OB02089E

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