Removing the β-hydroxy group from the prenylated tryptophan moiety of cyclomarins simplifies the synthesis of these interesting natural products significantly, without having a noteworthy effect on the anti-tuberculosis activity of the cyclomarins. In contrast, cyclomarazines did not show biological activity.
P. Barbie and U. Kazmaier, Org. Biomol. Chem., 2016, 14, 6055 DOI: 10.1039/C6OB00801A
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