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Issue 25, 2016
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Total synthesis of cyclomarins A, C and D, marine cyclic peptides with interesting anti-tuberculosis and anti-malaria activities

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Abstract

Cyclomarins are cyclic heptapeptides containing four unusual amino acids. New synthetic protocols toward their synthesis have been developed, leading to the synthesis and biological evaluation of three natural occurring cyclomarins. Interestingly, cyclomarins address two completely different targets: Clp C1, a subunit of the caseinolytic protease of Mycobacterium tuberculosis (MTB), as well as PfAp3Ase of Plasmodium falciparum. Therefore, cyclomarins are interesting lead structures for the development of drugs against tuberculosis and malaria.

Graphical abstract: Total synthesis of cyclomarins A, C and D, marine cyclic peptides with interesting anti-tuberculosis and anti-malaria activities

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Publication details

The article was received on 14 Apr 2016, accepted on 19 May 2016 and first published on 31 May 2016


Article type: Paper
DOI: 10.1039/C6OB00800C
Citation: Org. Biomol. Chem., 2016,14, 6036-6054
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    Total synthesis of cyclomarins A, C and D, marine cyclic peptides with interesting anti-tuberculosis and anti-malaria activities

    P. Barbie and U. Kazmaier, Org. Biomol. Chem., 2016, 14, 6036
    DOI: 10.1039/C6OB00800C

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