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Issue 25, 2016
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Recent applications in natural product synthesis of dihydrofuran and -pyran formation by ring-closing alkene metathesis

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Abstract

In the past two decades, alkene metathesis has risen in prominence to become a significant synthetic strategy for alkene formation. Many total syntheses of natural products have used this transformation. We review the use, from 2003 to 2015, of ring-closing alkene metathesis (RCM) for the generation of dihydrofurans or -pyrans in natural product synthesis. The strategies used to assemble the RCM precursors and the subsequent use of the newly formed unsaturation will also be highlighted and placed in context.

Graphical abstract: Recent applications in natural product synthesis of dihydrofuran and -pyran formation by ring-closing alkene metathesis

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Publication details

The article was received on 18 Mar 2016, accepted on 13 Apr 2016 and first published on 25 Apr 2016


Article type: Review Article
DOI: 10.1039/C6OB00593D
Citation: Org. Biomol. Chem., 2016,14, 5875-5893
  • Open access: Creative Commons BY license
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    Recent applications in natural product synthesis of dihydrofuran and -pyran formation by ring-closing alkene metathesis

    R. Jacques, R. Pal, N. A. Parker, C. E. Sear, P. W. Smith, A. Ribaucourt and D. M. Hodgson, Org. Biomol. Chem., 2016, 14, 5875
    DOI: 10.1039/C6OB00593D

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