Jump to main content
Jump to site search

Issue 25, 2016
Previous Article Next Article

Total synthesis, biosynthesis and biological profiles of clavine alkaloids

Author affiliations

Abstract

This review highlights noteworthy synthetic and biological aspects of the clavine subfamily of ergot alkaloids. Recent biosynthetic insights have laid the groundwork for a better understanding of the diverse biological pathways leading to these indole derivatives. Ergot alkaloids were among the first fungal-derived natural products identified, inspiring pharmaceutical applications in CNS disorders, migraine, infective diseases, and cancer. Pergolide, for example, is a semi-synthetic clavine alkaloid that has been used to treat Parkinson's disease. Synthetic activities have been particularly valuable to facilitate access to rare members of the Clavine family and empower medicinal chemistry research. Improved molecular target identification tools and a better understanding of signaling pathways can now be deployed to further extend the biological and medical utility of Clavine alkaloids.

Graphical abstract: Total synthesis, biosynthesis and biological profiles of clavine alkaloids

Back to tab navigation

Publication details

The article was received on 24 Apr 2016, accepted on 17 May 2016 and first published on 17 May 2016


Article type: Review Article
DOI: 10.1039/C6OB00878J
Citation: Org. Biomol. Chem., 2016,14, 5894-5913
  •   Request permissions

    Total synthesis, biosynthesis and biological profiles of clavine alkaloids

    S. R. McCabe and P. Wipf, Org. Biomol. Chem., 2016, 14, 5894
    DOI: 10.1039/C6OB00878J

Search articles by author

Spotlight

Advertisements