Jump to main content
Jump to site search

Issue 7, 2016
Previous Article Next Article

Developing and understanding biofluid vibrational spectroscopy: a critical review

Author affiliations

Abstract

Vibrational spectroscopy can provide rapid, label-free, and objective analysis for the clinical domain. Spectroscopic analysis of biofluids such as blood components (e.g. serum and plasma) and others in the proximity of the diseased tissue or cell (e.g. bile, urine, and sputum) offers non-invasive diagnostic/monitoring possibilities for future healthcare that are capable of rapid diagnosis of diseases via specific spectral markers or signatures. Biofluids offer an ideal diagnostic medium due to their ease and low cost of collection and daily use in clinical biology. Due to the low risk and invasiveness of their collection they are widely welcomed by patients as a diagnostic medium. This review underscores recent research within the field of biofluid spectroscopy and its use in myriad pathologies such as cancer and infectious diseases. It highlights current progresses, advents, and pitfalls within the field and discusses future spectroscopic clinical potentials for diagnostics. The requirements and issues surrounding clinical translation are also considered.

Graphical abstract: Developing and understanding biofluid vibrational spectroscopy: a critical review

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 27 Jul 2015 and first published on 27 Nov 2015


Article type: Review Article
DOI: 10.1039/C5CS00585J
Citation: Chem. Soc. Rev., 2016,45, 1803-1818
  •   Request permissions

    Developing and understanding biofluid vibrational spectroscopy: a critical review

    M. J. Baker, S. R. Hussain, L. Lovergne, V. Untereiner, C. Hughes, R. A. Lukaszewski, G. Thiéfin and G. D. Sockalingum, Chem. Soc. Rev., 2016, 45, 1803
    DOI: 10.1039/C5CS00585J

Search articles by author