Jump to main content
Jump to site search

Issue 7, 2016
Previous Article Next Article

Development of deep subsurface Raman spectroscopy for medical diagnosis and disease monitoring

Author affiliations

Abstract

The recently developed array of Raman spectroscopy techniques for deep subsurface analysis of biological tissues unlocks new prospects for medical diagnosis and monitoring of various biological conditions. The central pillars of these methods comprise spatially offset Raman spectroscopy (SORS) and Transmission Raman Spectroscopy facilitating penetration depths into tissue up to two orders of magnitude greater than those achievable with conventional Raman spectroscopy. This article reviews these concepts and discusses their emerging medical applications including non-invasive breast cancer diagnosis, cancer margin evaluation, bone disorder detection and glucose level determination.

Graphical abstract: Development of deep subsurface Raman spectroscopy for medical diagnosis and disease monitoring

Back to tab navigation

Publication details

The article was received on 15 Jun 2015 and first published on 12 Oct 2015


Article type: Tutorial Review
DOI: 10.1039/C5CS00466G
Author version
available:
Download author version (PDF)
Citation: Chem. Soc. Rev., 2016,45, 1794-1802
  • Open access: Creative Commons BY license
  •   Request permissions

    Development of deep subsurface Raman spectroscopy for medical diagnosis and disease monitoring

    P. Matousek and N. Stone, Chem. Soc. Rev., 2016, 45, 1794
    DOI: 10.1039/C5CS00466G

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements