Issue 31, 2016
From the journal:

Chemical Communications

Triggered and catalyzed self-assembly of hyperbranched DNA structures for logic operations and homogeneous CRET biosensing of microRNA†

Sai Bi,*a   Shuzhen Yue,a   Qiang Wub  and  Jiayan Yec  

* Corresponding authors

a Collaborative Innovation Center for Marine Biomass Fiber Materials and Textiles, College of Chemistry and Chemical Engineering, Laboratory of Fiber Materials and Modern Textiles, the Growing Base for State Key Laboratory, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Qingdao University, Qingdao 266071, P. R. China
E-mail: bisai11@126.com

b Key Laboratory for Sustainable Development of Marine Fisheries, Ministry of Agriculture, Shandong Provincial Key Laboratory for Fishery Resources and Eco-environment, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, P. R. China

c Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China

Abstract

Toehold-mediated strand displacement-based nanocircuits are developed by integrating catalytic hairpin assembly (CHA) with hybridization chain reaction (HCR), which achieves self-assembly of hyperbranched DNA structures and is readily utilized as an enzyme-free amplifier for homogeneous CRET detection of microRNA with high sensitivity and selectivity.

Graphical abstract: Triggered and catalyzed self-assembly of hyperbranched DNA structures for logic operations and homogeneous CRET biosensing of microRNA

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Article information

DOI
https://doi.org/10.1039/C6CC01308B
Article type
Communication
Submitted
11 Feb 2016
Accepted
15 Mar 2016
First published
15 Mar 2016

Chem. Commun., 2016,52, 5455-5458

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Triggered and catalyzed self-assembly of hyperbranched DNA structures for logic operations and homogeneous CRET biosensing of microRNA

S. Bi, S. Yue, Q. Wu and J. Ye, Chem. Commun., 2016, 52, 5455 DOI: 10.1039/C6CC01308B

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