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Issue 45, 2016
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Synthesis of PANI/hematite/PB hybrid nanocomposites and fabrication as screen printed paper based sensors for cholesterol detection

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Abstract

In this work, the composites of polyaniline/nano-hematite (α-Fe2O3)/Prussian Blue (PB) were successfully synthesized via a sonochemical method. This nanocomposite (PB/CPANI) has been used for the modification of paper-based sensors for cholesterol detection. The electrochemical studies of this nanocomposite showed a well-defined cyclic voltammogram for hydrogen peroxide (H2O2) with a remarkable electrochemical sensitivity. This nanocomposite modified paper-based electrode also showed excellent electrocatalytic activity towards H2O2 in the interference-free cathodic region. In addition, cholesterol oxidase was immobilized on the PB/CPANI-modified paper-based electrode for selective detection of cholesterol. Under optimum conditions, a linear range of 0.6–6.0 mM with a very low detection limit of 0.52 mM for cholesterol and a good sensitivity of 411.7 μA mM−1 cm−2 were obtained which indicated that the method presented is outstandingly appropriate to determine cholesterol in bovine serum albumin. This work might be an alternative, interference-free, and cost-effective approach for biomonitoring of cholesterol both in methodological studies and in clinical laboratories.

Graphical abstract: Synthesis of PANI/hematite/PB hybrid nanocomposites and fabrication as screen printed paper based sensors for cholesterol detection

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Publication details

The article was received on 03 Sep 2016, accepted on 13 Oct 2016 and first published on 14 Oct 2016


Article type: Paper
DOI: 10.1039/C6AY02478E
Citation: Anal. Methods, 2016,8, 8049-8058
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    Synthesis of PANI/hematite/PB hybrid nanocomposites and fabrication as screen printed paper based sensors for cholesterol detection

    F. N. Maluin, S. M., P. Rattanarat, W. Siangproh, O. Chailapakul, I. A. M. and N. S. A. Manan, Anal. Methods, 2016, 8, 8049
    DOI: 10.1039/C6AY02478E

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