Jump to main content
Jump to site search

Issue 33, 2015
Previous Article Next Article

Disulfide-bridged peptide macrobicycles from nature

Author affiliations

Abstract

Disulfide-bridged peptide bicycles (DBPBs) are molecules that contain a transannular disulfide bridge within a macrocyclic framework. While DBPBs are precedented in nature, the development of synthetic analogues and their use as therapeutic agents has yet to realize their full potential. A series of naturally-occurring DBPBs and their respective structural and biological features is presented, followed by a description of synthetic methods used to prepare and understand these unique bicyclic systems. The synergy of high-throughput biology and synthetic chemistry should facilitate the development of novel DBPBs in the near future.

Graphical abstract: Disulfide-bridged peptide macrobicycles from nature

Back to tab navigation

Publication details

The article was received on 04 Jun 2015, accepted on 23 Jun 2015 and first published on 23 Jun 2015


Article type: Review Article
DOI: 10.1039/C5OB01115A
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2015,13, 8768-8779
  •   Request permissions

    Disulfide-bridged peptide macrobicycles from nature

    B. K. W. Chung and A. K. Yudin, Org. Biomol. Chem., 2015, 13, 8768
    DOI: 10.1039/C5OB01115A

Search articles by author

Spotlight

Advertisements