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Issue 10, 2015
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Synthesis and DNA binding profile of N-mono- and N,N′-disubstituted indolo[3,2-b]carbazoles

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Abstract

A series of N-monosubstituted and N,N′-disubstituted derivatives of the indolo[3,2-b]carbazole chromophore have been prepared, and their binding affinity for duplex DNA has been evaluated by ultraviolet and fluorescence spectroscopies. It has been found that indolo[3,2-b]carbazoles bearing basic N-alkyl substituents are intercalators that bind DNA with affinities in the micromolar and submicromolar range and a preference for associating with sequences of mixed composition and purine-pyrimidine steps.

Graphical abstract: Synthesis and DNA binding profile of N-mono- and N,N′-disubstituted indolo[3,2-b]carbazoles

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Publication details

The article was received on 09 Dec 2014, accepted on 22 Jan 2015 and first published on 22 Jan 2015


Article type: Communication
DOI: 10.1039/C4OB02566K
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2015,13, 2879-2883
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    Synthesis and DNA binding profile of N-mono- and N,N′-disubstituted indolo[3,2-b]carbazoles

    H. K. Panesar, J. Solano and T. G. Minehan, Org. Biomol. Chem., 2015, 13, 2879
    DOI: 10.1039/C4OB02566K

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