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Issue 1, 2015
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The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

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Abstract

A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor®. The corresponding oxazoles can then be obtained via a packed reactor containing commercial manganese dioxide.

Graphical abstract: The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

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Publication details

The article was received on 02 Oct 2014, accepted on 27 Oct 2014 and first published on 28 Oct 2014


Article type: Paper
DOI: 10.1039/C4OB02105C
Citation: Org. Biomol. Chem., 2015,13, 207-214
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    The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

    S. Glöckner, D. N. Tran, R. J. Ingham, S. Fenner, Z. E. Wilson, C. Battilocchio and S. V. Ley, Org. Biomol. Chem., 2015, 13, 207
    DOI: 10.1039/C4OB02105C

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