Issue 1, 2015

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

Abstract

A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor®. The corresponding oxazoles can then be obtained via a packed reactor containing commercial manganese dioxide.

Graphical abstract: The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

Supplementary files

Article information

Article type
Paper
Submitted
02 Oct 2014
Accepted
27 Oct 2014
First published
28 Oct 2014
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2015,13, 207-214

Author version available

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions

S. Glöckner, D. N. Tran, R. J. Ingham, S. Fenner, Z. E. Wilson, C. Battilocchio and S. V. Ley, Org. Biomol. Chem., 2015, 13, 207 DOI: 10.1039/C4OB02105C

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