Jump to main content
Jump to site search

Issue 64, 2015
Previous Article Next Article

Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue

Author affiliations

Abstract

A near-infrared fluorescent probe based on methylene blue (p-NBMB) was developed for the detection of nitroreductase. Conjugating methylene blue with a p-nitrobenzyl moiety enables it to be activated by nitroreductase-catalyzed 1,6-elimination, resulting in the release of an active methylene blue fluorophore.

Graphical abstract: Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue

Back to tab navigation

Supplementary files

Publication details

The article was received on 07 May 2015, accepted on 06 Jul 2015 and first published on 06 Jul 2015


Article type: Communication
DOI: 10.1039/C5CC03824C
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2015,51, 12787-12790
  •   Request permissions

    Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue

    J. Bae, L. E. McNamara, M. A. Nael, F. Mahdi, R. J. Doerksen, G. L. Bidwell, N. I. Hammer and S. Jo, Chem. Commun., 2015, 51, 12787
    DOI: 10.1039/C5CC03824C

Search articles by author

Spotlight

Advertisements