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Issue 12, 2015
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Biocatalytic conversion of ethylene to ethylene oxide using an engineered toluene monooxygenase

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Abstract

Mutants of toluene o-xylene monooxygenase are demonstrated to oxidize ethylene to ethylene oxide in vivo at yields of >99%. The best mutant increases ethylene oxidation activity by >5500-fold relative to the native enzyme. This is the first report of a recombinant enzyme capable of carrying out this industrially significant chemical conversion.

Graphical abstract: Biocatalytic conversion of ethylene to ethylene oxide using an engineered toluene monooxygenase

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Publication details

The article was received on 04 Nov 2014, accepted on 12 Dec 2014 and first published on 05 Jan 2015


Article type: Communication
DOI: 10.1039/C4CC08802F
Citation: Chem. Commun., 2015,51, 2283-2285
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    Biocatalytic conversion of ethylene to ethylene oxide using an engineered toluene monooxygenase

    D. A. Carlin, S. J. Bertolani and J. B. Siegel, Chem. Commun., 2015, 51, 2283
    DOI: 10.1039/C4CC08802F

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