Issue 12, 2015

Aerobic C–N bond activation: a simple strategy to construct pyridines and quinolines

Abstract

Inspired by the autoxidation processes, a dioxygen induced C–N bond activation of primary alkyl amines was demonstrated toward the synthesis of pyridines and quinolines. The transition-metal free conditions with O2 as the sole oxidant make this transformation very attractive. Notably, the substrate applicability of different kinds of ketones is greatly broadened for this transformation.

Graphical abstract: Aerobic C–N bond activation: a simple strategy to construct pyridines and quinolines

Supplementary files

Article information

Article type
Communication
Submitted
13 Oct 2014
Accepted
17 Dec 2014
First published
18 Dec 2014

Chem. Commun., 2015,51, 2286-2289

Aerobic C–N bond activation: a simple strategy to construct pyridines and quinolines

K. Wu, Z. Huang, C. Liu, H. Zhang and A. Lei, Chem. Commun., 2015, 51, 2286 DOI: 10.1039/C4CC08074B

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