The synthesis of head-to-tail cyclic sulfono-γ-AApeptides

Haifan Wu; Fengyu She; Wenyang Gao; Austin Prince; Yaqiong Li; Lulu Wei; Allison Mercer; Lukasz Wojtas; Shengqian Ma; Jianfeng Cai

doi:10.1039/C4OB02232G

The synthesis of head-to-tail cyclic sulfono-γ-AApeptides†

Haifan Wu,^a Fengyu She,^a Wenyang Gao,^a Austin Prince,^a Yaqiong Li,^a Lulu Wei,^a Allison Mercer,^a Lukasz Wojtas,^a Shengqian Ma^a and Jianfeng Cai*^a

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^a Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, FL 33620, USA
E-mail: jianfengcai@usf.edu

Abstract

We report an efficient method for the preparation of unprecedented head-to-tail cyclic sulfono-γ-AApeptides. Following this method, a number of cyclic sequences bearing two to five subunits were efficiently synthesized. In addition, the X-ray crystal structure study of a three-membered cyclic sulfono-γ-AApeptide revealed a type II β-turn-like character.

Organic & Biomolecular Chemistry

The synthesis of head-to-tail cyclic sulfono-γ-AApeptides†

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The synthesis of head-to-tail cyclic sulfono-γ-AApeptides

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