Issue 45, 2014
From the journal:

Organic & Biomolecular Chemistry

Catalyst-free reductive amination of aromatic aldehydes with ammonium formate and Hantzsch ester†

Pan-Pan Zhao,a   Xin-Feng Zhou,a   Jian-Jun Dai*a  and  Hua-Jian Xu*ab  

* Corresponding authors

a School of Medical Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, China
E-mail: hjxu@hfut.edu.cn

b Key Laboratory of Advanced Functional Materials and Devices, Anhui Province, China

Abstract

The protocol of the reductive amination of aromatic aldehydes using ammonium formate and Hantzsch ester is described. It is a mild, convenient, acid- and catalyst-free system applied for the synthesis of both symmetric and asymmetric aromatic secondary amines.

Graphical abstract: Catalyst-free reductive amination of aromatic aldehydes with ammonium formate and Hantzsch ester

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Article information

DOI
https://doi.org/10.1039/C4OB01590H
Article type
Communication
Submitted
27 Jul 2014
Accepted
18 Sep 2014
First published
18 Sep 2014

Org. Biomol. Chem., 2014,12, 9092-9096

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Catalyst-free reductive amination of aromatic aldehydes with ammonium formate and Hantzsch ester

P. Zhao, X. Zhou, J. Dai and H. Xu, Org. Biomol. Chem., 2014, 12, 9092 DOI: 10.1039/C4OB01590H

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