Jump to main content
Jump to site search

Issue 33, 2014
Previous Article Next Article

Asymmetric synthesis of substituted NH-piperidines from chiral amines

Author affiliations

Abstract

Previously, we reported an efficient asymmetric synthesis of substituted piperidines through an exocyclic chirality induced nitroalkene/amine/enone (NAE) condensation reaction. An effective protecting group strategy was developed herein to achieve enantiopure piperidines (yields up to 92%) with complete chirality retention (ee > 95%). A simple derivatization of the obtained piperidines gave thiourea catalysts, indicating the strong potential of this method for producing new amine-based dual functional organocatalysts for future development.

Graphical abstract: Asymmetric synthesis of substituted NH-piperidines from chiral amines

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Mar 2014, accepted on 14 May 2014 and first published on 15 May 2014


Article type: Paper
DOI: 10.1039/C4OB00657G
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2014,12, 6384-6388
  •   Request permissions

    Asymmetric synthesis of substituted NH-piperidines from chiral amines

    L. N. Gautam, Y. Su, N. G. Akhmedov, J. L. Petersen and X. Shi, Org. Biomol. Chem., 2014, 12, 6384
    DOI: 10.1039/C4OB00657G

Search articles by author

Spotlight

Advertisements