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Issue 8, 2014
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Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages

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Abstract

RNA sequences having up to three consecutive internal amide linkages were synthesized and studied using UV and NMR spectroscopy. The amide modifications did not interfere with normal base-pairing and A-type RNA conformation. Three consecutive amides were well tolerated in the passenger strand of siRNA and caused little change in RNAi activity.

Graphical abstract: Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages

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Publication details

The article was received on 18 Dec 2013, accepted on 06 Jan 2014 and first published on 07 Jan 2014


Article type: Communication
DOI: 10.1039/C3OB42532K
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2014,12, 1207-1210
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    Synthesis, biophysical studies and RNA interference activity of RNA having three consecutive amide linkages

    P. Tanui, S. D. Kennedy, B. D. Lunstad, A. Haas, D. Leake and E. Rozners, Org. Biomol. Chem., 2014, 12, 1207
    DOI: 10.1039/C3OB42532K

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