Issue 8, 2014
From the journal:

Organic & Biomolecular Chemistry

NBS mediated nitriles synthesis through C[double bond, length as m-dash]C double bond cleavage†

Xiaolin Zong,a   Qing-Zhong Zhenga  and  Ning Jiao*ab  

* Corresponding authors

a State Key Laboratory of Natural and Biomimetic Drugs, Peking University, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191, China
E-mail: jiaoning@bjmu.edu.cn
Fax: (+86)-010-8280-5297
Tel: (+86)-01082805297

b Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China

Abstract

An NBS mediated nitriles synthesis through C[double bond, length as m-dash]C double bond cleavage has been developed. TMSN3 was employed as the nitrogen source for this Cu(OAc)2 promoted nitrogenation reaction. This transformation has a relatively high regio-selectivity to form aromatic nitriles.

Graphical abstract: NBS mediated nitriles synthesis through C [[double bond, length as m-dash]] C double bond cleavage

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Article information

DOI
https://doi.org/10.1039/C3OB42118J
Article type
Communication
Submitted
24 Oct 2013
Accepted
27 Nov 2013
First published
28 Nov 2013

Org. Biomol. Chem., 2014,12, 1198-1202

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NBS mediated nitriles synthesis through C[double bond, length as m-dash]C double bond cleavage

X. Zong, Q. Zheng and N. Jiao, Org. Biomol. Chem., 2014, 12, 1198 DOI: 10.1039/C3OB42118J

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