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Issue 2, 2015
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Highly effective design strategy for the heterogenisation of chemo- and enantioselective organocatalysts

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Abstract

We have demonstrated that the covalent heterogenisation of two homogeneous organocatalysts, cinchonine and 1,4-diazabicyclo[2.2.2]octane, onto the inner walls of mesoporous silica supports results in highly active and selective solid catalysts that are easily recoverable and recyclable. We have further highlighted the efficacy of our design rationale and its amenability for tailoring the nature of the active site via meticulous choice of pore-aperture and hydrophobicity to create a superior heterogenised analogue for Michael addition and Baylis Hillman reactions. It is envisaged that this immobilisation strategy could be rationally extended to the heterogenisation of a plethora of organocatalysts.

Graphical abstract: Highly effective design strategy for the heterogenisation of chemo- and enantioselective organocatalysts

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The article was received on 09 Jul 2014, accepted on 04 Sep 2014 and first published on 04 Sep 2014


Article type: Communication
DOI: 10.1039/C4CY00895B
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Citation: Catal. Sci. Technol., 2015,5, 660-665
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    Highly effective design strategy for the heterogenisation of chemo- and enantioselective organocatalysts

    S. H. Newland, D. J. Xuereb, E. Gianotti, L. Marchese, R. Rios and R. Raja, Catal. Sci. Technol., 2015, 5, 660
    DOI: 10.1039/C4CY00895B

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