Issue 97, 2014
From the journal:

Chemical Communications

Palladium-catalyzed oxidative C–H bond acylation of N-nitrosoanilines with toluene derivatives: a traceless approach to synthesize N-alkyl-2-aminobenzophenones†

Yinuo Wu,a   Ling-Jun Feng,a   Xiao Lu,a   Fuk Yee Kwong*b  and  Hai-Bin Luo*a  

* Corresponding authors

a School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
E-mail: luohb77@mail.sysu.edu.cn
Fax: +86-20-3994-3000

b State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong
E-mail: fuk-yee.kwong@polyu.edu.hk
Fax: +852-2364-9932

Abstract

A palladium-catalyzed cascade cross-coupling of N-nitroso-anilines and toluene derivatives for the direct synthesis of N-alkyl-2-aminobenzophenones is described. N-nitroso groups in anilines can act as the traceless directing groups while toluene derivatives can serve as effective acyl precursors under mild reaction conditions.

Graphical abstract: Palladium-catalyzed oxidative C–H bond acylation of N-nitrosoanilines with toluene derivatives: a traceless approach to synthesize N-alkyl-2-aminobenzophenones

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Article information

DOI
https://doi.org/10.1039/C4CC07440H
Article type
Communication
Submitted
20 Sep 2014
Accepted
15 Oct 2014
First published
15 Oct 2014

Chem. Commun., 2014,50, 15352-15354

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Palladium-catalyzed oxidative C–H bond acylation of N-nitrosoanilines with toluene derivatives: a traceless approach to synthesize N-alkyl-2-aminobenzophenones

Y. Wu, L. Feng, X. Lu, F. Y. Kwong and H. Luo, Chem. Commun., 2014, 50, 15352 DOI: 10.1039/C4CC07440H

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