A novel graphene oxide based fluorescent nanosensing strategy with hybridization chain reaction signal amplification for highly sensitive biothiol detection

Abstract

A novel fluorescent nanosensor has been developed for detecting biothiols including cysteine and glutathione using graphene oxide based hairpin DNA-selective fluorescence quenching and thymine–Hg(II)–thymine coordination-controlled hybridization chain reaction, which provides a simple but the most sensitive platform for biothiol assays.