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Issue 67, 2014
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Pyrazine-derived disulfide-reducing agent for chemical biology

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Abstract

For fifty years, dithiothreitol (DTT) has been the preferred reagent for the reduction of disulfide bonds in proteins and other biomolecules. Herein we report on the synthesis and characterization of 2,3-bis(mercaptomethyl)pyrazine (BMMP), a readily accessible disulfide-reducing agent with reactivity under biological conditions that is markedly superior to DTT and other known reagents.

Graphical abstract: Pyrazine-derived disulfide-reducing agent for chemical biology

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Publication details

The article was received on 13 Jun 2014, accepted on 20 Jun 2014 and first published on 11 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC04491F
Citation: Chem. Commun., 2014,50, 9591-9594
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    Pyrazine-derived disulfide-reducing agent for chemical biology

    J. C. Lukesh, III, K. K. Wallin and R. T. Raines, Chem. Commun., 2014, 50, 9591
    DOI: 10.1039/C4CC04491F

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