Issue 86, 2014

Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

Abstract

Inspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of DNA nanostructures using a single-stranded circular DNA template. The amplified DNA nanostructures have shown efficient delivery of folic acid (FA) conjugated siRNAs into KB cells with a dose dependent gene silencing.

Graphical abstract: Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

Supplementary files

Article information

Article type
Communication
Submitted
20 May 2014
Accepted
16 Jun 2014
First published
17 Jun 2014

Chem. Commun., 2014,50, 13049-13051

Author version available

Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates

C. A. Hong, B. Jang, E. H. Jeong, H. Jeong and H. Lee, Chem. Commun., 2014, 50, 13049 DOI: 10.1039/C4CC03834G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements