Issue 23, 2014

Rational design of biotin–disulfide–coumarin conjugates: a cancer targeted thiol probe and bioimaging

Abstract

Biotin–disulfide–coumarin conjugates are designed and synthesized as novel fluorescent sensors for cancer targeted intracellular thiol imaging in living organisms. In vitro experiments disclose that probe 6 is preferentially taken up by biotin receptor-positive A549 tumor cells through receptor mediated endocytosis.

Graphical abstract: Rational design of biotin–disulfide–coumarin conjugates: a cancer targeted thiol probe and bioimaging

Supplementary files

Article information

Article type
Communication
Submitted
27 Dec 2013
Accepted
27 Jan 2014
First published
29 Jan 2014

Chem. Commun., 2014,50, 3044-3047

Rational design of biotin–disulfide–coumarin conjugates: a cancer targeted thiol probe and bioimaging

D. Jung, S. Maiti, J. H. Lee, J. H. Lee and J. S. Kim, Chem. Commun., 2014, 50, 3044 DOI: 10.1039/C3CC49790A

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