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Issue 23, 2014
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A new strategy to construct a C[double bond, length as m-dash]C–CF3 subunit via CuBr-catalyzed domino reaction of homopropargyl amines: an efficient synthesis of trifluoromethyl containing building blocks 4-trifluoromethyl-2,3-dihydro-pyrroliums

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Abstract

A new strategy for the construction of a C[double bond, length as m-dash]C–CF3 subunit has been developed via CuBr-catalyzed domino cyclization–trifluoromethylation of homopropargyl amines with Umemoto's reagent. 4-Trifluoromethyl-2,3-dihydro-pyrroliums were produced in high yields. The usefulness of these products has been demonstrated by the transformation of them into various other trifluoromethylated molecules.

Graphical abstract: A new strategy to construct a C [[double bond, length as m-dash]] C–CF3 subunit via CuBr-catalyzed domino reaction of homopropargyl amines: an efficient synthesis of trifluoromethyl containing building blocks 4-trifluoromethyl-2,3-dihydro-pyrroliums

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Publication details

The article was received on 27 Nov 2013, accepted on 24 Jan 2014 and first published on 27 Jan 2014


Article type: Communication
DOI: 10.1039/C3CC49059A
Citation: Chem. Commun., 2014,50, 3048-3051
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    A new strategy to construct a C[double bond, length as m-dash]C–CF3 subunit via CuBr-catalyzed domino reaction of homopropargyl amines: an efficient synthesis of trifluoromethyl containing building blocks 4-trifluoromethyl-2,3-dihydro-pyrroliums

    G. Ge, X. Huang, C. Ding, S. Wan, L. Dai and X. Hou, Chem. Commun., 2014, 50, 3048
    DOI: 10.1039/C3CC49059A

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