Issue 17, 2014
From the journal:

Chemical Communications

Highly regioselective and chemoselective titanocene mediated Barbier-type allylation reactions†

Sara P. Morcillo,a   Ángela Martínez-Peragón,a   Verena Jakoby,b   Antonio J. Mota,c   Christian Kube,b   José Justicia,a   Juan M. Cuerva*a  and  Andreas Gansäuer*b  

* Corresponding authors

a Department of Organic Chemistry, University of Granada, Fuentenueva Campus, Granada 18071, Spain
E-mail: jmcuerva@ugr.es

b Kekulé-Institut für Organische Chemie und Biochemie, Universität Bonn, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany
E-mail: andreas.gansaeuer@uni-bonn.de

c Department of Inorganic Chemistry, University of Granada, Fuentenueva Campus, Granada 18071, Spain

Abstract

Titanocene carboxylate 1 is an excellent chemoselective reagent for unprecedented α-regioselective Barbier-type reactions. It constitutes the first titanocene(III) able to tolerate epoxides and readily reduced carbonyl compounds, such as aromatic and α,β-unsaturated aldehydes.

Graphical abstract: Highly regioselective and chemoselective titanocene mediated Barbier-type allylation reactions

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Article information

DOI
https://doi.org/10.1039/C3CC49230C
Article type
Communication
Submitted
04 Dec 2013
Accepted
24 Dec 2013
First published
06 Jan 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 2211-2213

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Highly regioselective and chemoselective titanocene mediated Barbier-type allylation reactions

S. P. Morcillo, Á. Martínez-Peragón, V. Jakoby, A. J. Mota, C. Kube, J. Justicia, J. M. Cuerva and A. Gansäuer, Chem. Commun., 2014, 50, 2211 DOI: 10.1039/C3CC49230C

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