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Issue 5, 2014
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Incorporation of sulfated hyaluronic acid macromers into degradable hydrogel scaffolds for sustained molecule delivery

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Abstract

Synthetically sulfated hyaluronic acid (HA) has been shown to bind proteins with high affinity through electrostatic interactions. While HA-based hydrogels have been used widely in recent years for drug delivery and tissue engineering applications, incorporation of sulfated HA into these networks to attenuate the release of proteins is yet to be explored. Here, we developed sulfated and methacrylate-modified HA macromers and incorporated them into HA hydrogels through free radical-initiated crosslinking. The sulfated HA macromers bound to a heparin-binding protein (i.e., stromal cell-derived factor-1 alpha, SDF-1α) with an affinity comparable to heparin and did not alter the gelation behavior or network mechanics when copolymerized into hydrogels at low concentrations. Further, these macromers were incorporated into electrospun nanofibrous hydrogels to introduce sulfate groups into macroporous scaffolds. Once incorporated into either uniform or fibrous HA hydrogels, the sulfated HA macromers significantly slowed encapsulated SDF-1α release over 12 days. Thus, these macromers provide a useful way to introduce heparin-binding features into radical-crosslinked hydrogels to alter protein interactions for a range of applications.

Graphical abstract: Incorporation of sulfated hyaluronic acid macromers into degradable hydrogel scaffolds for sustained molecule delivery

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Publication details

The article was received on 24 Sep 2013, accepted on 22 Oct 2013 and first published on 08 Nov 2013


Article type: Paper
DOI: 10.1039/C3BM60227C
Citation: Biomater. Sci., 2014,2, 693-702
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    Incorporation of sulfated hyaluronic acid macromers into degradable hydrogel scaffolds for sustained molecule delivery

    B. P. Purcell, I. L. Kim, V. Chuo, T. Guenin, S. M. Dorsey and J. A. Burdick, Biomater. Sci., 2014, 2, 693
    DOI: 10.1039/C3BM60227C

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