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Issue 21, 2014
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Label free detection of specific protein binding using a microwave sensor

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Abstract

The specific binding of streptavidin to biotinylated protein A was demonstrated using a microwave detection system. In control experiments, the degree of non-specific binding was negligible. The method of detection was used to monitor the adsorption of two other proteins, cytochrome c and glucose oxidase, on to the IDE microwave sensor surface. The response of the sensor was also examined on different substrate materials, with detection of protein binding observed obtained on both smooth, conductive (gold) and on rough, insulating (hydroxyapatite) surfaces.

Graphical abstract: Label free detection of specific protein binding using a microwave sensor

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Publication details

The article was received on 19 May 2014, accepted on 04 Aug 2014 and first published on 04 Aug 2014


Article type: Communication
DOI: 10.1039/C4AN00909F
Citation: Analyst, 2014,139, 5335-5338
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    Label free detection of specific protein binding using a microwave sensor

    M. Salazar-Alvarez, O. Korostynska, A. Mason, A. Al-Shamma'a, J. C. Cooney, E. Magner and S. A. M. Tofail, Analyst, 2014, 139, 5335
    DOI: 10.1039/C4AN00909F

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