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Issue 2, 2012
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Photoactivated nanomaterials for biomedical release applications

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Abstract

The achievement of nanomaterials able to release therapeutic agents in a controlled fashion is a major challenge in the burgeoning field of nanomedicine. Light represents the most elegant and non-invasive trigger to deliver bio-active compounds on demand since it allows the accurate control of three key factors determining the therapeutic outcome including site, timing and dosage. Recent breakthroughs in nanotechnology offer the opportunity to characterize, manipulate and organize matter at the nanometre scale, controlling the size and shape of the resulting nanomaterials and greatly improving the biocompatibility and the cellular uptake efficiency. This feature article illustrates some recent advances in the fabrication of light-triggered nanomaterials for biomedical delivery, describing representative examples from our laboratory and others, underlying the logical design and highlighting the potential applications in some major areas such as drug and gene release, photodynamic and photothermal therapy.

Graphical abstract: Photoactivated nanomaterials for biomedical release applications

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Publication details

The article was received on 13 Jul 2011, accepted on 30 Sep 2011 and first published on 16 Nov 2011


Article type: Feature Article
DOI: 10.1039/C1JM13288A
Citation: J. Mater. Chem., 2012,22, 301-318
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    Photoactivated nanomaterials for biomedical release applications

    S. Sortino, J. Mater. Chem., 2012, 22, 301
    DOI: 10.1039/C1JM13288A

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