Issue 40, 2012

A TEMPO-conjugated fluorescent probe for monitoring mitochondrial redox reactions

Abstract

We report a mitochondrial targeted redox probe (MitoRP) that comprises a nitroxide radical (TEMPO) moiety and coumarin 343. Using isolated mitochondria in the presence/absence of substrates and inhibitors of oxidative phosphorylation, we demonstrated that MitoRP is a useful probe to monitor the electron flow associated with complex I.

Graphical abstract: A TEMPO-conjugated fluorescent probe for monitoring mitochondrial redox reactions

Supplementary files

Article information

Article type
Communication
Submitted
27 Jan 2012
Accepted
28 Mar 2012
First published
29 Mar 2012

Chem. Commun., 2012,48, 4845-4847

A TEMPO-conjugated fluorescent probe for monitoring mitochondrial redox reactions

S. Hirosawa, S. Arai and S. Takeoka, Chem. Commun., 2012, 48, 4845 DOI: 10.1039/C2CC30603D

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