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Issue 6, 2012
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A multi-component domino reaction for the direct access to polyfunctionalized indolesvia intermolecular allylic esterification and indolation

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Abstract

A novel multi-component reaction for the synthesis of polyfunctionalized indoles and bis-indoles has been established. The reaction pathways were controlled by varying enamines with different substitution patterns to give polyfunctionalized indoles and bis-indoles selectively. The reaction proceeds at a fast speed within 15–30 min with water as the major byproduct, which makes work-up convenient.

Graphical abstract: A multi-component domino reaction for the direct access to polyfunctionalized indolesvia intermolecular allylic esterification and indolation

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Publication details

The article was received on 23 Sep 2011, accepted on 18 Oct 2011 and first published on 31 Oct 2011


Article type: Communication
DOI: 10.1039/C1CC15913E
Citation: Chem. Commun., 2012,48, 808-810
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    A multi-component domino reaction for the direct access to polyfunctionalized indolesvia intermolecular allylic esterification and indolation

    B. Jiang, M. Yi, F. Shi, S. Tu, S. Pindi, P. McDowell and G. Li, Chem. Commun., 2012, 48, 808
    DOI: 10.1039/C1CC15913E

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