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Issue 38, 2011
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Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy

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Abstract

The binding behaviour of labeling molecule copper phthalocyanine tetrasulfonate sodium (PcCu(SO3Na)4) on the assemblies of representative polyamino acids has been studied by using scanning tunneling microscopy (STM). By directly visualizing the adsorption and distribution of the labeling species on the peptide assemblies in STM images, one could obtain relative binding affinities of the labeling molecule with different amino acid residues.

Graphical abstract: Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy

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Publication details

The article was received on 23 Apr 2011, accepted on 09 Aug 2011 and first published on 25 Aug 2011


Article type: Communication
DOI: 10.1039/C1CC12380G
Citation: Chem. Commun., 2011,47, 10638-10640
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    Determination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy

    C. Wang, X. Mao, A. Yang, L. Niu, S. Wang, D. Li, Y. Guo, Y. Wang, Y. Yang and C. Wang, Chem. Commun., 2011, 47, 10638
    DOI: 10.1039/C1CC12380G

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