Molecular design and evaluation of quinoxaline-carbohydrate hybrids as novel and efficient photo-induced GG-selective DNA cleaving agents
Abstract
Quinoxaline, found in antitumor quinoxaline antibiotics, was found to cleave double stranded DNA at the 5′ side guanine of 5′-GG-3′ site on irradiation with long wavelength UV light without any additive; furthermore, a bis(quinoxaline–carbohydrate) hybrid system was very effective for DNA cleavage.