Recognition of platinum(ii) amine complexes by nucleotides: role ofphosphate and carbonyl groups in ([15N3]diethylenetriamine)-(guanosine 5′-monophosphate)platinum(ii)

Abstract

Two-dimensional [ ¹ H, ¹⁵ N] NMR studies show that in the model monofunctional DNA adduct [Pt([ ¹⁵ N ₃ ]dien)(5′-GMP-N ⁷ )] ²⁺ [5′-GMP = guanosine 5′-monophosphate, dien = 1,5-diamino-3-azapentane (prepared by a novel synthesis from glycine)], stereospecific hydrogen-bonding interactions involving Pt–NH protons are promoted by deprotonation of both the 5′-phosphate group and N ¹ H of coordinated 5′-GMP.